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Biotransformation of quinoxaline by Streptomyces badius
Author(s) -
Sutherland J.B.,
Evans F.E.,
Freeman J.P.,
Williams A.J.
Publication year - 1996
Publication title -
letters in applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.698
H-Index - 110
eISSN - 1472-765X
pISSN - 0266-8254
DOI - 10.1111/j.1472-765x.1996.tb01142.x
Subject(s) - biotransformation , quinoxaline , streptomyces , mass spectrometry , chemistry , streptomycetaceae , ethyl acetate , nuclear magnetic resonance spectroscopy , actinomycetales , chromatography , biology , stereochemistry , biochemistry , bacteria , organic chemistry , enzyme , genetics
J.B. SUTHERLAND, F.E. EVANS, J.P. FREEMAN AND A.J. WILLIAMS. 1996. Quinoxaline, a mutagenic azaarene produced in foods during cooking, was added to cultures of Streptomyces badius ATCC 39117. After 24 h, the cultures were extracted with extracted with ethyl acetate. Two major metabolites were purified by liquid chromatography and identified by mass spectrometry and nuclear magnetic resonance spectroscopy as 3,4–dihydro‐2(1 H )‐quinoxalinone and 2(1 H )‐quinoxalinone.