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Mode of action of acidocin 8912, a bacteriocin produced by Lactobacillus acidophilus TK8912
Author(s) -
Tahara T.,
Oshimura M.,
Kanatani K.
Publication year - 1996
Publication title -
letters in applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.698
H-Index - 110
eISSN - 1472-765X
pISSN - 0266-8254
DOI - 10.1111/j.1472-765x.1996.tb00062.x
Subject(s) - lactobacillus acidophilus , bacteriocin , mode of action , microbiology and biotechnology , biology , lactobacillaceae , lactobacillus , bacteria , chemistry , probiotic , biochemistry , antimicrobial , genetics
T. TAHARA, M. OSHIMURA AND K. KANATANI. 1996. The mechanism of bactericidal activity of acidocin 8912, a bacteriocin produced by Lactobacillus acidophilus TK8912, was investigated. Acidocin 8912 dissipated the membrane potential and the pH gradient in sensitive Lactobacillus casei cells, which affected protonmotive force‐dependent processes such as amino acid transport. Acidocin 8912 also caused an efflux of glutamate, previously taken up via a unidirectional ATP‐driven transport system, possibly by causing pore formation in the cytoplasmic membrane. The results suggest that the inhibitory action of acidocin 8912 against sensitive Lact. casei cells is directed at the cytoplasmic membrane and that growth inhibition may be caused by the dissipation of the protonmotive force and by pore formation.