Premium
Dermonecrotic activity of a cell wall preparation from Fusobacterium necrophorum
Author(s) -
Kanoe M.,
Abe K.,
Kai K.,
Blobel H.
Publication year - 1995
Publication title -
letters in applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.698
H-Index - 110
eISSN - 1472-765X
pISSN - 0266-8254
DOI - 10.1111/j.1472-765x.1995.tb00412.x
Subject(s) - fusobacterium necrophorum , cell wall , microbiology and biotechnology , cytoplasm , cell , bacteroidaceae , toxin , bacteria , erythema , fusobacterium , biology , chemistry , biochemistry , immunology , genetics , bacteroides
A cell wall preparation of Fusobacterium necrophorum induced haemorrhagic necrosis in the skins of guinea pigs and rabbits. Effects in mice and rats were weak or absent. The toxic activity of the cell wall preparation was not reduced by heat treatment. A dermonecrotic toxin was isolated from the cell wall preparation with sodium dodecylsulphate and concentrated by precipitation with ethanol. A preparation of the bacterial cytoplasm from Fus. necrophorum induced mainly erythema.