Premium
Antagonists of bacitracin
Author(s) -
Podlesek Z.,
Comino A.
Publication year - 1994
Publication title -
letters in applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.698
H-Index - 110
eISSN - 1472-765X
pISSN - 0266-8254
DOI - 10.1111/j.1472-765x.1994.tb00916.x
Subject(s) - library science , bacitracin , classics , microbiology and biotechnology , history , biology , computer science , antibiotics
Three groups of substances were identified which inhibit the bactericidal activity of bacitracin. Beside two divalent metals, Mg 2+ and Ca 2+ , and a metabolite with chelating properties, citrate, the most pronounced effect was observed with pyrophosphate. Metals probably prevent access of bacitracin to the lipid carrier whereas metabolites with chelating properties deprive the bacitracin of a metal ion needed for its binding to the lipid carrier. Pyrophosphate, effective as an antagonist at very low concentrations, may intercept the binding of bacitracin to the pyrophosphate part of the target molecule.