Premium
Transformation of alpha‐santonin via two independent pathways by Pseudomonas strain S ATCC 43388
Author(s) -
Colaco D.,
Furtado I.,
Naik U. P.,
Mavinkurve S.,
Paknikar S. K.
Publication year - 1993
Publication title -
letters in applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.698
H-Index - 110
eISSN - 1472-765X
pISSN - 0266-8254
DOI - 10.1111/j.1472-765x.1993.tb01449.x
Subject(s) - biotransformation , strain (injury) , semicarbazide , transformation (genetics) , pseudomonas , alpha (finance) , stereochemistry , pseudomonadales , chemistry , pseudomonadaceae , pseudomonas aeruginosa , microbiology and biotechnology , bacteria , biology , biochemistry , enzyme , organic chemistry , gene , genetics , medicine , construct validity , nursing , patient satisfaction , anatomy
Pseudomonas strain S (ATCC 43388) transforms alpha‐santonin in the presence of dicyclohexylcarbodiimide (DCCD) to 1,2‐dihydrosantonin (DHS) and two more products, D1 and D2. D2 was identified as 4,5‐dihydroxysantonin (DHXS). Cells incubated with semicarbazide (SC) formed DHXS but not DHS. Simultaneous formation of DHS and DHXS is indicative of the presence of two distinct pathways of alpha‐santonin biotransformation.