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Antigenic glycolipids of Mycobacterium fortuitum based on trehalose acylated with 2‐methyloctadec‐2‐enoic acid
Author(s) -
Hamid M. E.,
Fraser J. L.,
Wallace P. A.,
Besra G. S.,
Goodfellow M.,
Minnikin D. E.,
Ridell M.
Publication year - 1993
Publication title -
letters in applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.698
H-Index - 110
eISSN - 1472-765X
pISSN - 0266-8254
DOI - 10.1111/j.1472-765x.1993.tb01377.x
Subject(s) - mycobacterium fortuitum , glycolipid , antiserum , mycobacterium kansasii , antigen , microbiology and biotechnology , biology , mycobacterium , biochemistry , trehalose , chemistry , bacteria , genetics
Three characteristic glycolipids were identified in extracts of 10 representative strains of Mycobacterium fortuitum. The two most polar major lipids were shown to be antigens with strong reactions against homologous antiserum and sera raised against Mycobacterium tuberculosis H37Rv. Both of these lipids were shown to be acyl trehaloses, containing substantial amounts of 2‐methyloctadec‐2‐enoic acid in addition to straight‐chain and monounsaturated acids. These lipids correspond to ‘mycoside F’, lipids previously identified by infra‐red spectroscopy in extracts of Myco. fortuitum.