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Fungistatic and fungicidal effects of the ionophores monensin and tetronasin on the rumen fungus Neocallimastix sp. LM1
Author(s) -
Phillips M.W.,
Gordon G.L.R.
Publication year - 1992
Publication title -
letters in applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.698
H-Index - 110
eISSN - 1472-765X
pISSN - 0266-8254
DOI - 10.1111/j.1472-765x.1992.tb00741.x
Subject(s) - commonwealth , monensin , rumen , fungicide , fungus , microbiology and biotechnology , biology , library science , food science , political science , law , botany , zoology , computer science , fermentation
The ionophore antibiotics monensin and tetronasin have been reported to inhibit anaerobic fungi in vitro , and are suitable for animal use. In this study, their effectiveness in removing the anaerobic fungus Neocallimastix sp. LM1 from the rumen was investigated in vitro. Both antibiotics were fungistatic: tetronasin at 0.5 μg/ml and monensin at 1.0 μg/ml; exposure for 24 h did not inhibit subsequent growth after removal of the ionophore. The ionophores were fungicidal at much higher concentrations, 1 μg/ml for tetronasin and 16 μg/ml for monensin. It seems likely that the combination of relatively high inhibitory dose and the fungistatic nature of monensin would explain difficulties in using this compound to eliminate anaerobic fungi from the rumens of experimental animals.