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Effect of cacao husk extract on human immunodeficiency virus infection
Author(s) -
Unten S.,
Ushijima H.,
Shimizu H.,
Tsuchie H.,
Kitamura T.,
Moritome N.,
Sakagami H.
Publication year - 1991
Publication title -
letters in applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.698
H-Index - 110
eISSN - 1472-765X
pISSN - 0266-8254
DOI - 10.1111/j.1472-765x.1991.tb00621.x
Subject(s) - cytopathic effect , syncytium , virology , virus , husk , biology , cell culture , lymphoblast , lysis , microbiology and biotechnology , botany , genetics
A sodium hydroxide extract from cacao husk inhibited the cytopathic effect of human immunodeficiency virus type 1 (HIV‐1) against HTLV‐1‐transformed T‐cell lines MT‐2 and MT‐4. It also inhibited syncytium formation between HIV‐infected and uninfected lymphoblastoid T‐cell line, MOLT‐4. The anti‐HIV activity was concentrated by membrane filter fractionation to a fraction with molecular weight of 100–300 KDa. Anti‐HIV activity of the extract was attributable to interference with the virus adsorption, rather than to inhibition of the virus replication after adsorption.