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Primary interactions of taurulatam solutions with a urinary tract clinical isolate of Escherichia coli and mammalian erythrocytes
Author(s) -
Jones D. S.,
Gorman S. P.,
Woolfson A. D.,
McCafferty D. F.
Publication year - 1990
Publication title -
letters in applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.698
H-Index - 110
eISSN - 1472-765X
pISSN - 0266-8254
DOI - 10.1111/j.1472-765x.1990.tb00183.x
Subject(s) - escherichia coli , metabolite , adsorption , microbiology and biotechnology , enterobacteriaceae , urinary system , chemistry , hydrolysis , bacteria , formaldehyde , biology , biochemistry , gene , organic chemistry , genetics , endocrinology
The primary interaction of taurultam with both Escherichia coli (isolated from a urinary tract infection) and mammalian erythrocytes was studied at 37d̀C. Using E. coli as the adsorbate, the adsorption of taurultam was observed to follow a constant partitioning (C) isotherm. However, the interaction between taurultam and mammalian erythrocytes was shown to follow a Langmuirian (L) pattern. It is postulated that this difference may be due to the hydrolysis of taurultam by the bacterial cell after adsorption with the subsequent liberation of formaldehyde and the metabolite, taurinamide.