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Reduced adherence and inhibition of hyphal development of Candida albicans by the antimicrobial agent polynoxylin
Author(s) -
Gorman S.P.,
McCafferty D.F.,
Woolfson A.D.,
Kennedy G.E.
Publication year - 1988
Publication title -
letters in applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.698
H-Index - 110
eISSN - 1472-765X
pISSN - 0266-8254
DOI - 10.1111/j.1472-765x.1988.tb01235.x
Subject(s) - candida albicans , antimicrobial , microbiology and biotechnology , corpus albicans , hypha , buccal administration , strain (injury) , biology , chemistry , pharmacology , anatomy
Polynoxylin (Anaflex R) was investigated for antimicrobial activities ancillary to its known cidal and static effects. Significant reductions in adherence of Candida albicans blastospores (oral strain) to human buccal epithelial cells were observed following polynoxylin treatment. The anti‐adherence activity was concentration and time‐dependent. Treatment of the epithelial cells did not result in significant reductions in adherence. Polynoxylin was also shown to inhibit the germination and hyphal development of C. albicans.