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Uptake of noxythiolin by a urinary isolate of Escherichia coli
Author(s) -
MCCAFFERTY D. F.,
GORMAN S. P.,
WOOLFSON A. D.,
ANDERSON L.
Publication year - 1987
Publication title -
letters in applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.698
H-Index - 110
eISSN - 1472-765X
pISSN - 0266-8254
DOI - 10.1111/j.1472-765x.1987.tb01581.x
Subject(s) - queen (butterfly) , pharmacy , library science , northern ireland , medicine , history , family medicine , biology , zoology , ethnology , computer science , hymenoptera
The uptake of noxythiolin by a urinary isolate of Escherichia coli was examined initially at 37°C but the adsorption isotherm was complicated by the concomitant degradation of the compound. When drug adsorption was investigated at 4°C, to reduce the degradation rate of the compound, it was observed that noxythiolin was taken up by the urinary isolate in a linear fashion. The resulting adsorption patterns are discussed in relation to their possible classification. The implications of this uptake are considered with respect to the antimicrobial activity of noxythiolin.