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Antimicrobial activity of some alkyltrimethylammonium bromides
Author(s) -
Gilbert P.,
Altaae A.
Publication year - 1985
Publication title -
letters in applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.698
H-Index - 110
eISSN - 1472-765X
pISSN - 0266-8254
DOI - 10.1111/j.1472-765x.1985.tb01498.x
Subject(s) - antimicrobial , staphylococcus aureus , substituent , chemistry , alkyl , pseudomonas aeruginosa , saccharomyces cerevisiae , stereochemistry , minimum inhibitory concentration , biochemistry , biology , bacteria , yeast , organic chemistry , genetics
n‐Alkyltrimethylammonium bromides (CnTAB) have been synthesized with n‐alkyl chain lengths of between C 5 and C 22 . Antimicrobial activity was assessed as growth inhibitory activity (MIC) towards seven representative strains of micro‐organisms and as bacterial activity towards Staphylococcus aureus, Saccharomyces cerevisiae and Pseudomonas aeruginosa . These data indicated that whilst the level of activity was generally parabolically related to n‐alkyl chain length, separate dependencies existed for short (n < 10) and long (n > 10) chain substituents, with disproportionately large increases in activity, in the order of three log cycles, occurring as substituent chain lengths increased from n = 10 to n = 12. This is interpreted in terms of distinct mechanisms of action, binding site and/or physicochemical properties for extreme members of the series.