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The mode of action of l,2‐benzisothiazolin‐3‐one on Staphylococcus aureus
Author(s) -
Fuller S. J.,
Denyer S. P.,
Hugo W. B.,
Pemberton D.,
Woodcock P. M.,
Buckley A. J.
Publication year - 1985
Publication title -
letters in applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.698
H-Index - 110
eISSN - 1472-765X
pISSN - 0266-8254
DOI - 10.1111/j.1472-765x.1985.tb01478.x
Subject(s) - pharmacy , library science , action (physics) , sociology , history , medicine , family medicine , computer science , physics , quantum mechanics
1,2‐benzisothiazolin‐3‐one (BIT), at growth inhibitory concentrations, has little effect on membrane integrity but significantly inhibits the active transport and oxidation of glucose by washed Staphylococcus aureus cells. The dependancy of these metabolic processes on thiol‐containing enzymes and the observed interaction of BIT with glutathione and isolated enzyme preparations suggests that cellular thiol groups are a major target for BIT.