Premium
Stroke outcome in the ketogenic state – a systematic review of the animal data
Author(s) -
Gibson Claire L.,
Murphy Anne N.,
Murphy Sean P.
Publication year - 2012
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.2012.07943.x
Subject(s) - ketogenic diet , stroke (engine) , ketone bodies , medicine , meta analysis , pathological , systematic review , medline , bioinformatics , epilepsy , biology , psychiatry , mechanical engineering , biochemistry , metabolism , engineering
As a predictor of potential clinical outcome, we performed a systematic review of controlled studies that assessed experimental stroke outcome in rodents maintained on special diets (calorie restriction and ketogenic diet) or following the direct administration of ketone bodies. Pre‐clinical studies were identified by searching web databases and the reference lists of relevant original articles and reviews. Sixteen published studies (a total of 733 experimental animals) met specific criteria and were analyzed using Cochrane Review Manager software. This resulted in objective evidence to suggest beneficial effects of the ketogenic pathway on pathological and functional outcomes following experimental stroke.