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Cerebrospinal fluid α‐synuclein levels are elevated in multiple sclerosis and neuromyelitis optica patients during replase
Author(s) -
Wang Honghao,
Wang Kai,
Xu Wen,
Wang Conghui,
Qiu Wei,
Zhong Xiaonan,
Dai Yongqiang,
Wu Aimin,
Hu Xueqiang
Publication year - 2012
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.2012.07749.x
Subject(s) - neuromyelitis optica , multiple sclerosis , cerebrospinal fluid , pathogenesis , medicine , pathological , parkinson's disease , demyelinating disease , alpha synuclein , pathology , disease , expanded disability status scale , neurodegeneration , neuroscience , immunology , biology
J. Neurochem. (2012) 122 , 19–23. Abstract The concept that the immune system plays a central role in the pathogenesis of multiple sclerosis (MS) and neuromyelitis optica (NMO) was indisputable. However, neurodegenerative pathological features including loss of axons and neurons were also found in the lesions of these diseases. α‐Synuclein is one of the most abundant proteins in pre‐synaptic terminals. Recently, many research show α‐synuclein level in CSF may reflect the progression of synaptic dysfunction and neuronal apoptosis. Whether the levels of CSF α‐synuclein are changed in MS and NMO patients remain unknown. In this study, CSF α‐synuclein was measured by an enzyme‐linked immunosorbent assay (ELISA) in MS ( n = 18) patients, NMO ( n = 22) patients, Parkinson’s disease patients ( n = 9), and the controls ( n = 11). We found concentration of α‐synuclein in MS and NMO patients were significantly higher than Parkinson’s disease subgroup and the controls. Both MS and NMO revealed an increased disease disability with increased CSF α‐synuclein. Thus, CSF α‐synuclein may be reflect injure axons and neurons in inflammatory demyelinating diseases.