Premium
Amyloid β: linking synaptic plasticity failure to memory disruption in Alzheimer’s disease
Author(s) -
Ma Tao,
Klann Eric
Publication year - 2012
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.2011.07506.x
Subject(s) - neuroscience , synaptic plasticity , disease , dementia , alzheimer's disease , amyloid (mycology) , long term potentiation , medicine , psychology , pathology , receptor
J. Neurochem. (2012) 120 (Suppl. 1), 140–148. Abstract Mounting evidence suggests that amyloid beta‐induced impairments in synaptic plasticity that is accompanied by cognitive decline and dementia represent key pathogenic steps of Alzheimer’s disease. In this study, we review recent advances in the study of the molecular and cellular mechanisms underlying Alzheimer’s disease‐associated synaptic dysfunction and memory deficits, and how these mechanisms could provide novel avenues for therapeutic intervention to treat this devastating neurodegenerative disease.