Premium
The emerging role of trace amine‐associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity
Author(s) -
Miller Gregory M.
Publication year - 2011
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.2010.07109.x
Subject(s) - monoamine neurotransmitter , dopaminergic , neuroscience , monoaminergic , dopamine , pharmacology , amphetamine , vesicular monoamine transporter , medicine , biology , receptor , serotonin
J. Neurochem. (2011) 116 , 164–176. Abstract It is now recognized that trace amine associated‐receptor 1 (TAAR1) plays a functional role in the regulation of brain monoamines and the mediation of action of amphetamine‐like psychostimulants. Accordingly, research on TAAR1 opens the door to a new avenue of approach for medications development to treat drug addiction as well as the spectrum of neuropsychiatric disorders hallmarked by aberrant regulation of brain monoamines. This overview focuses on recent studies which reveal a role for TAAR1 in the functional regulation of monoamine transporters and the neuronal regulatory mechanisms that modulate dopaminergic activity.