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Regulation of ryanodine receptors by dopamine D 1 receptors during methamphetamine‐induced place conditioning
Author(s) -
Kurokawa Kazuhiro,
Mizuno Koji,
Shibasaki Masahiro,
Ohkuma Seitaro
Publication year - 2010
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.2010.07010.x
Subject(s) - sulpiride , ryanodine receptor , dopamine , conditioned place preference , methamphetamine , meth , chemistry , medicine , endocrinology , dopamine receptor , receptor , pharmacology , biology , dopaminergic , monomer , organic chemistry , acrylate , polymer
J. Neurochem. (2010) 115 , 1206–1214. Abstract Little is known about ryanodine receptors (RyRs) related to the methamphetamine (METH)‐induced place preference. The present study was designed to ascertain whether RyRs could play a role in the development of METH‐induced place preference in the mouse. The METH‐induced place preference was dose‐dependently suppressed by dantrolene, a RyRs receptor antagonist. The levels of RyRs 1 and 2 in the frontal cortex and RyRs 1 in the limbic forebrain were significantly increased in METH‐conditioned mice. This up‐regulation of RyRs were not inhibited by nifedipine. Both the dopamine D 1 receptor antagonist SCH23390 and the dopamine D 2 receptor antagonist sulpiride inhibited the development of METH‐induced place conditioning. In contrast, the increases of RyRs 1 and 2 in the frontal cortex and of RyRs 1 in the limbic forebrain were completely abolished by SCH23390, whereas sulpiride had no effect. These findings indicate that up‐regulation of RyRs is regulated through the activation of dopamine D 1 receptors in the METH‐conditioning.