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Neuropeptide S stimulates dopaminergic neurotransmission in the medial prefrontal cortex
Author(s) -
Si Wei,
Aluisio Leah,
Okamura Naoe,
Clark Stewart D.,
Fraser Ian,
Sutton Steven W.,
Bonaventure Pascal,
Reinscheid Rainer K.
Publication year - 2010
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.2010.06947.x
Subject(s) - dopamine , microdialysis , serotonergic , neurotransmission , prefrontal cortex , neuroscience , dopaminergic , serotonin , neurotransmitter , chemistry , catecholaminergic , endocrinology , medicine , psychology , central nervous system , receptor , cognition
J. Neurochem. (2010) 115 , 475–482. Abstract Neuropeptide S (NPS) is known to produce anxiolytic‐like effects and facilitate extinction of conditioned fear. Catecholaminergic neurotransmission in the medial prefrontal cortex (mPFC) has been suggested to be crucially involved in these brain functions. In the current study, we investigated the effect of NPS on the release of dopamine and serotonin in the mPFC by in vivo microdialysis in rats. Central administration of NPS dose‐dependently enhanced extracellular levels of dopamine and its major metabolite 3,4‐dihydroxyphenylacetic acid, with maximal effects lasting up to 120 min. In contrast, no effect on serotonergic neurotransmission was detected. Dopamine release in the mPFC has been previously linked to modulation of anxiety states and fear extinction. The present results may thus provide a physiological and anatomical basis for the reported effects of NPS on these behaviors.