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Axon‐oligodendrocyte interactions during developmental myelination, demyelination and repair
Author(s) -
Piaton Gabrièle,
Gould Robert M.,
Lubetzki Catherine
Publication year - 2010
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.2010.06831.x
Subject(s) - remyelination , oligodendrocyte , neuroscience , myelin , multiple sclerosis , axon , biology , neuroprotection , myelinogenesis , demyelinating disorder , central nervous system , immunology
J. Neurochem. (2010) 114 , 1243–1260. Abstract In multiple sclerosis, CNS demyelination is often followed by spontaneous repair, mostly achieved by adult oligodendrocyte precursor cells. Extent of this myelin repair differs, ranging from very low, limited to the plaque border, to extensive, with remyelination throughout the ‘shadow plaques.’ In addition to restoring neuronal connectivity, new myelin is neuroprotective. It reduces axonal loss and thus disability progression. Reciprocal communication between neurons and oligodendrocytes is essential for both myelin biogenesis and myelin repair. Hence, deciphering neuron‐oligodendrocyte communication is not only important for understanding myelination per se , but also the pathophysiology that underlies demyelinating diseases and the development of innovative therapeutic strategies.