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Off‐line concomitant release of dopamine and glutamate involvement in taste memory consolidation
Author(s) -
GuzmánRamos Kioko,
OsorioGómez Daniel,
MorenoCastilla Perla,
BermúdezRattoni Federico
Publication year - 2010
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.2010.06758.x
Subject(s) - microdialysis , dopaminergic , neuroscience , dopamine , glutamate receptor , memory consolidation , taste aversion , nmda receptor , psychology , tetrodotoxin , stimulation , neurotransmitter , chemistry , taste , biology , receptor , endocrinology , central nervous system , biochemistry , hippocampus
J. Neurochem. (2010) 114 , 226–236. Abstract It has been postulated that memory consolidation process requires post‐learning molecular changes that will support long‐term experiences. In the present study, we assessed with in vivo microdialysis and capillary electrophoresis whether such changes involve the release of neurotransmitters at post‐acquisition stages. Using conditioned taste aversion paradigm we observed spontaneous off‐line (i.e. in absence of stimulation) dopamine and glutamate reactivation within the insular cortex about 45 min after the stimuli association. These increments did not appear in control groups that were unable to acquire the task, and it seems to be dependent on amygdala activity since its reversible inactivation by tetrodotoxin impaired cortical off‐line release of both neurotransmitters and memory consolidation. In addition, blockade of dopaminergic D1 and/or NMDA receptors before the off‐line activity impaired long‐ but not short‐term memory. These results suggest that off‐line extracellular increments of glutamate and dopamine have a significant functional role in consolidation of taste memory.