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Thursday Oral Session
Author(s) -
K Yanai,
N Okamura,
Neurodegeneration Villemagne,
Austin Health,
Disease Shearman,
H Okano,
E Syková,
A Privat,
F Perrin,
C Serguera,
A A Velumian,
M G Fehlings,
E Molnar,
K Cho,
G L Collingridge,
J H Zhang,
Chen,
W Ostrowski,
R Chen,
F R Sharp,
R Vemuganti,
T Hartman,
Retinoblastoma Ajioka,
K Nakajima,
M A Dyer,
H G Lee,
X Zhu,
S L Richardson,
G Perry,
M A Smith,
Galve-Roperh,
J Guzmán,
Apoptosis Ahn,
S B Lee,
K H Lee,
P J Crouch,
L W Hung,
C P Soon,
P A Adlard,
A I Bush,
C L Masters,
Q X Li,
P S Donnelly,
K J Barnham,
A R White,
A R Cole,
A Kumar,
R Goyal,
A Prakash,
F Bharathi,
T M Dawson
Publication year - 2009
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.2009.06241.x
Subject(s) - thursday , session (web analytics) , citation , library science , computer science , world wide web , linguistics , philosophy
The proteome of the synapse comprises 1–2000 proteins organised into multiprotein complexes with modular molecular network architecture. Proteomics reveals that postsynaptic neurotransmitter receptors are organised with 100–200 proteins embedded within the postsynaptic density (PSD). Phosphoproteomics shows activation of glutamate and dopamine receptors drive networks of hundreds of proteins and phosphorylation sites that orchestrate the output on many classes of proteins. These postsynaptic phosphoproteome networks include switching and regulatory components that result in a postsynaptic computational system of extraordinary complexity and informational processing capacity. We studied the origins and evolution of synapses and found that an ancestral protosynapse originating in unicellular animals predated the neuronal synapse of metazoans. The protosynapse was elaborated upon by the addition of specific classes of signaling proteins in metazoans and a further increase in complexity in chordates. The evolutionary expansion in synapse proteome complexity has contributed to the signaling networks and forms of plasticity found in higher species. Importantly, this complexity which predated the evolution of the large regionalised brain of vertebrates was exploited to provide novel neuronal types and synapses in different brain regions. Thus synapse proteome evolution are a template for the origins and complexity of nervous systems. We are now studying how synapse evolution gave rise to different behavioural traits and physiological mechanisms.