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Author(s) -
Yuan, T,
Liang, Y,
Tay, DKC,
So, KF,
Ellis-Behnke, RG
Publication year - 2009
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.2009.06238.x
Subject(s) - session (web analytics) , citation , computer science , library science , information retrieval , world wide web
Adult neurogenesis happens continuously in olfactory bulb. Loss of
sensory input to the olfactory bulb leads to decreased formation of
new neurons in the bulb. Piriform cortex receives projection from
ipsilateral olfactory bulb, and previous studies proved the existence
of new neurons in adult piriform cortex under physiological
conditions. However the effects of olfactory bulb input deprivation
on adult neurogenesis in rat piriform cortex have not been
investigated before. The existence of neuronal progenitor cells in adult rat piriform cortex were confirmed with Bromodeoxyuridine
(BrdU) labeling and early neuronal markers such as doublecortin
(DCX) and Polysialic Acid-NCAM (PSA-NCAM). Sensory deprivation
to the piriform cortex achieved by transection of the olfactory
tract at the caudal part of one olfactory bulb, before the frontal
sinus, leads to a significant increase (~60%) of doublecortin positive
cells in the ipsilateral piriform cortex compared with the contralateral
(intact) side. Because deafferentation causes cell apoptosis, it is
possible that deafferentation or local cell death can enhance the
recruitment of new neurons in the piriform cortex.link_to_OA_fulltex