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Muscleblind‐like 2: circadian expression in the mammalian pineal gland is controlled by an adrenergic‐cAMP mechanism
Author(s) -
Kim JongSo,
Coon Steven L.,
Weller Joan L.,
Blackshaw Seth,
Rath Martin F.,
Møller Morten,
Klein David C.
Publication year - 2009
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.2009.06184.x
Subject(s) - circadian rhythm , pineal gland , biology , medicine , endocrinology , alternative splicing , period (music) , rhythm , mechanism (biology) , rna splicing , melatonin , microbiology and biotechnology , rna , messenger rna , genetics , gene , philosophy , physics , epistemology , acoustics
Muscleblind‐like 2 (Mbnl2) is a zinc finger protein first identified in Drosophila. It appears to be essential for photoreceptor development and to be involved in RNA splicing. Here we report that Mbnl2 is strongly expressed in the rat pineal gland. The abundance of pineal Mbnl2 transcripts follows a marked circadian rhythm with peak levels approximately sevenfold higher at night than day levels. Mbnl2 protein exhibits a similar rhythm. In vitro studies indicate that the abundance of Mbnl2 transcripts and protein are controlled by an adrenergic/cAMP mechanism.