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The amyloid hypothesis for Alzheimer’s disease: a critical reappraisal
Author(s) -
Hardy John
Publication year - 2009
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.2009.06181.x
Subject(s) - biochemistry of alzheimer's disease , disease , alzheimer's disease , amyloid (mycology) , neuroscience , pathogenesis , amyloid precursor protein , psychology , medicine , pathology
The amyloid hypothesis has been the basis for most work on the pathogenesis of Alzheimer’s disease. Recent clinical trials based on this hypothesis have been inconclusive. In this article I review the current status of the hypothesis and suggest that a major scientific need is to understand the normal function of amyloid‐β precursor protein (APP) and think how this may relate to the cell death in the disease process.