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AMPK in the brain: its roles in energy balance and neuroprotection
Author(s) -
Ronnett Gabriele V.,
Ramamurthy Santosh,
Kleman Amy M.,
Landree Leslie E.,
Aja Susan
Publication year - 2009
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.2009.05916.x
Subject(s) - ampk , neuroprotection , protein kinase a , neuroscience , energy balance , balance (ability) , amp activated protein kinase , adenosine , stroke (engine) , biology , kinase , endocrinology , microbiology and biotechnology , ecology , mechanical engineering , engineering
Abstract Adenosine monophosphate‐activated protein kinase (AMPK) senses metabolic stress and integrates diverse physiological signals to restore energy balance. Multiple functions are indicated for AMPK in the CNS. While all neurons sense their own energy status, some integrate neuro‐humoral signals to assess organismal energy balance. A variety of disease states may involve AMPK, so determining the underlying mechanisms is important. We review the impact of altered AMPK activity under physiological (hunger, satiety) and pathophysiological (stroke) conditions, as well as therapeutic manipulations of AMPK that may improve energy balance.