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Nicotine increases dopamine clearance in medial prefrontal cortex in rats raised in an enriched environment
Author(s) -
Zhu Jun,
Bardo Michael T.,
Green Thomas A.,
Wedlund Peter J.,
Dwoskin Linda P.
Publication year - 2007
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.2007.04951.x
Subject(s) - striatum , dopamine , neurochemical , nicotine , saline , chemistry , prefrontal cortex , dopamine transporter , endocrinology , 3,4 dihydroxyphenylacetic acid , medicine , neuroscience , homovanillic acid , psychology , dopaminergic , biochemistry , receptor , serotonin , cognition
Environmental enrichment results in differential behavioral and neurochemical responsiveness to nicotine. The present study investigates dopamine clearance (CL DA ) in striatum and medial prefrontal cortex (mPFC) using in vivo voltammetry in rats raised in enriched (EC) or impoverished conditions (IC) and administered nicotine (0.4 mg/kg) or saline. Baseline CL DA in striatum or mPFC was not different between EC and IC. Across repeated DA application, striatal CL DA increased in saline‐control EC and IC. CL DA increased in mPFC in saline‐control IC; CL DA did not change in saline‐control EC. Thus, enrichment differentially alters dynamic responses of the dopamine transporter (DAT) to repeated DA application in mPFC, but not in striatum. In EC, nicotine increased mPFC CL DA compared to saline‐control, but had no effect on CL DA in IC; nicotine had no effect in striatum in EC or IC. Compared to respective saline‐controls, nicotine increased dihydroxyphenylacetic acid content in striatum and mPFC in EC, but not in IC. Nicotine also had no effect on DA content in striatum or mPFC in EC or IC. Results indicate that enrichment eliminated the dynamic response of mPFC DAT to repeated DA application in saline‐control and augmented the nicotine‐induced increase in DAT function in mPFC, but not in striatum.