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Alzheimer’s disease: the lipid connection
Author(s) -
Hartmann Tobias,
Kuchenbecker Johannna,
Grimm Marcus O. W.
Publication year - 2007
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.2007.04715.x
Subject(s) - pathogenesis , disease , sphingolipid , etiology , polyunsaturated fatty acid , alzheimer's disease , cholesterol , amyloid (mycology) , medicine , neuroscience , chemistry , biochemistry , biology , pathology , fatty acid
Alzheimer’s disease is the most common neurodegenerative disorder. This short review summarizes the current knowledge about the role of lipids, especially cholesterol, sphingolipids, plasmalogens, and polyunsaturated fatty acids in Alzheimer’s disease etiology, pathogenesis, risk‐factors, prevention, treatment, and the function of the amyloid precursor protein and the amyloid peptides in lipid homeostasis.