Premium
Neurodevelopmental involvement in schizophrenia: the olfactory epithelium as an alternative model for research
Author(s) -
Cascella Nicola G.,
Takaki Manabu,
Lin Sandra,
Sawa Akira
Publication year - 2007
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.2007.04628.x
Subject(s) - neuroscience , schizophrenia (object oriented programming) , olfactory epithelium , central nervous system , schizophrenia research , pathological , psychology , neurodevelopmental disorder , olfactory system , medicine , psychiatry , pathology , autism
It has been suggested that disturbances during neurodevelopment may play a crucial role in the etiology of schizophrenia (SZ). This premise is supported by brain imaging, epidemiological, and pathological studies as well as the discovery of susceptibility genes for SZ that appear to be implicated in development of the central nervous system. Here, we discuss the limitations of the current methods and models for studying the neurodevelopmental implications in SZ. We agree with the proposal that the olfactory epithelium, in which neurodevelopment continues throughout life, might represent an alternative model for understanding the pathophysiology of the disorder.