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Mechanisms of axon guidance: membrane dynamics and axonal transport in semaphorin signalling
Author(s) -
Mann Fanny,
Rougon Geneviève
Publication year - 2007
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.2007.04578.x
Subject(s) - semaphorin , growth cone , neuroscience , axon guidance , axon , neurite , axoplasmic transport , biology , plexin , microbiology and biotechnology , multicellular organism , sema3a , receptor , cell , biochemistry , in vitro
The intricate geometry of neuronal networks poses many unique cell‐biological problems regarding the way a growing axon responds to its environment. Several groups of ligand–receptor pairs have been identified to regulate such processes. In this study, we take class 3 semaphorins as an example and review what is known about the intracellular movements of semaphorins throughout neuronal cells, transport support structures and location of release sites. We discuss how their receptor trafficking may contribute to regulate membrane dynamics underlying growth cone motility and the physiological contribution made by class 3 semaphorins‐induced acceleration of axoplasmic transport on neurite development.