Premium
FGF signalling pathways in development of the midbrain and anterior hindbrain
Author(s) -
Partanen Juha
Publication year - 2007
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.2007.04463.x
Subject(s) - hindbrain , midbrain , neural tube , biology , neuroscience , rhombomere , fibroblast growth factor , fgf8 , axon guidance , cell fate determination , wnt signaling pathway , microbiology and biotechnology , central nervous system , axon , anatomy , signal transduction , genetics , receptor , embryo , hox gene , gene expression , gene , transcription factor
Development of the central nervous system is coordinated by intercellular signalling centres established within the neural tube. The isthmic organizer (IsO), located between the midbrain and anterior hindbrain, is one such centre. Important signal molecules secreted by the IsO include members of the fibroblast growth factor and Wnt families. These signals are integrated with dorsally and ventrally derived signals to regulate development of the midbrain and rhombomere 1 of the hindbrain. The IsO is operational for a remarkably long period of time. Depending on the developmental stage, it controls a variety of processes such as cell survival, cell identity, neural precursor proliferation, neuronal differentiation and axon guidance. This review focuses on the fibroblast growth factor signalling, its novel molecular regulatory mechanisms and how this pathway regulates multiple aspects of cell behaviour in the developing midbrain and anterior hindbrain.