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The structure of human collapsin response mediator protein 2, a regulator of axonal growth
Author(s) -
Stenmark Pål,
Ogg Derek,
Flodin Susanne,
Flores Alex,
Kotenyova Tetyana,
Nyman Tomas,
Nordlund Pär,
Kursula Petri
Publication year - 2007
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.2006.04401.x
Subject(s) - mediator , regulator , neuroscience , biology , microbiology and biotechnology , biochemistry , gene
Axonal growth cone guidance is a central process in nervous system development and repair. Collapsin response mediator protein 2 (CRMP‐2) is a neurite extension‐promoting neuronal cytosolic molecule involved in the signalling of growth inhibitory cues from external stimuli, such as semaphorin 3A and the myelin‐associated glycoprotein. We have determined the crystal structure of human tetrameric CRMP‐2, which is structurally related to the dihydropyriminidases; however, the active site is not conserved. The wealth of earlier functional mapping data for CRMP‐2 are discussed in light of the three‐dimensional structure of the protein. The differences in oligomerisation interfaces between CRMP‐1 and CRMP‐2 are used to model CRMP‐1/2 heterotetramers.