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Biphasic alterations in Serotonin‐1B (5‐HT 1B ) receptor function during abstinence from extended cocaine self‐administration
Author(s) -
O'Dell Laura E.,
Manzardo Ann M.,
Polis Ilham,
Stouffer David G.,
Parsons Loren H.
Publication year - 2006
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.2006.04163.x
Subject(s) - nucleus accumbens , abstinence , agonist , serotonin , dopamine , medicine , endocrinology , 5 ht receptor , self administration , receptor , psychology , pharmacology , psychiatry
Alterations in 5‐HT 1B receptor function during cocaine abstinence were evaluated in rats given either limited‐ or extended access (LA and EA, respectively) to cocaine self‐administration. The locomotor response to the 5‐HT 1B/1A agonist RU24969 was significantly reduced in cocaine‐experienced animals relative to cocaine‐naïve controls following 6 h of abstinence but became sensitized over the subsequent 14 days of abstinence. Both the early phase subsensitivity and later phase supersensivity to RU 24969‐induced activity were greater in EA versus LA animals. Intra‐nucleus accumbens administration of the 5‐HT 1B agonist CP 93, 129 produced significantly greater increases in dialysate dopamine levels in EA versus control animals following 14 days of abstinence. However, there was no difference between EA and cocaine‐naïve control animals in the augmentation of cocaine‐induced increases in nucleus accumbens DA produced by intra‐VTA CP 93, 129. Collectively these findings demonstrate that 5‐HT 1B receptor function is persistently altered by cocaine self‐administration.