Premium
Kiss‐and‐run and full‐collapse fusion as modes of exo‐endocytosis in neurosecretion
Author(s) -
Harata Nobutoshi C.,
Aravanis Alexander M.,
Tsien Richard W.
Publication year - 2006
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.2006.03987.x
Subject(s) - exocytosis , endocytosis , bulk endocytosis , neurosecretion , synaptic vesicle , kiss (tnc) , biology , microbiology and biotechnology , kiss and run fusion , vesicle , vesicle fusion , lipid bilayer fusion , synaptic vesicle recycling , neuroscience , cell , membrane , biochemistry , computer science , computer network
Neurotransmitters and hormones are released from neurosecretory cells by exocytosis (fusion) of synaptic vesicles, large dense‐core vesicles and other types of vesicles or granules. The exocytosis is terminated and followed by endocytosis (retrieval). More than fifty years of research have established full‐collapse fusion and clathrin‐mediated endocytosis as essential modes of exo‐endocytosis. Kiss‐and‐run and vesicle reuse represent alternative modes, but their prevalence and importance have yet to be elucidated, especially in neurons of the mammalian CNS. Here we examine various modes of exo‐endocytosis across a wide range of neurosecretory systems. Full‐collapse fusion and kiss‐and‐run coexist in many systems and play active roles in exocytotic events. In small nerve terminals of CNS, kiss‐and‐run has an additional role of enabling nerve terminals to conserve scarce vesicular resources and respond to high‐frequency inputs. Full‐collapse fusion and kiss‐and‐run will each contribute to maintaining cellular communication over a wide range of frequencies.