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Inositol 1,4,5‐trisphosphate (IP 3 ) receptors and their role in neuronal cell function
Author(s) -
Mikoshiba Katsuhiko
Publication year - 2006
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.2006.03985.x
Subject(s) - inositol , inositol trisphosphate receptor , endoplasmic reticulum , microbiology and biotechnology , receptor , inositol phosphate , chemistry , biology , biophysics , biochemistry
Inositol 1,4,5‐trisphosphate (IP 3 ) receptor is a Ca 2+ release channel localized on the endoplasmic reticulum (ER) and plays an important role in neuronal function. IP 3 receptor was discovered as a developmentally regulated protein missing in the cerebellar mutant mice. Recent studies indicate that IP 3 Rs are involved in early development and neuronal plasticity. IP 3 works to release IRBIT from the IP 3 binding core in addition to release Ca 2+ . IRBIT binds to and activates Na, Bicarbonate cotransporter. Electron microscopic study show the IP 3 receptor has allosteric property to change its form from square to windmill in the presence of Ca 2+ . IP 3 R associates with ERp44, a redox sensor, Homer, other proteins and is transported as vesicular ER on microtubules. All these data suggests IP 3 receptor/CA 2+ channel works as a signaling center inside cells.