Premium
Phosphoinositide regulation of neuroexocytosis: adding to the complexity
Author(s) -
Osborne Shona L.,
Wen Peter J.,
Meunier Frederic A.
Publication year - 2006
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.2006.03892.x
Subject(s) - exocytosis , synaptic vesicle , neurotransmitter , neurosecretion , synapsin , biology , vesicle , neuroscience , active zone , neurotransmitter agents , microbiology and biotechnology , chemistry , biochemistry , membrane , central nervous system
Exocytosis of neurotransmitter containing vesicles supports neuronal communication. The importance of molecular interactions involving specific lipids has become progressively more evident and the lipid composition of both the synaptic vesicle and the pre‐synaptic plasma membrane at the active zone has significant functional consequences for neurotransmitter release. Several classes of lipids have been implicated in exocytosis including polyunsaturated fatty acids and phosphoinositides. This minireview will focus on recent developments regarding the role of phosphoinositides in neurosecretion.