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ABCA2 is a marker of neural progenitors and neuronal subsets in the adult rodent brain
Author(s) -
Broccardo Cyril,
Nieoullon Vincent,
Amin Rada,
Masmejean Frédérique,
Carta Sonia,
Tassi Sara,
Pophillat Matthieu,
Rubartelli Anna,
Pierres Michel,
Rougon Geneviève,
Nieoullon André,
Chazal Genèvieve,
Chimini Giovanna
Publication year - 2006
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.2006.03714.x
Subject(s) - subventricular zone , neurogenesis , biology , neural stem cell , dentate gyrus , subgranular zone , neuroscience , hippocampal formation , nestin , neuroepithelial cell , microbiology and biotechnology , progenitor cell , hippocampus , stem cell
The notion that the ATP‐binding cassette transporter‐A2 (ABCA2) may be involved in brain sterol homeostasis and is associated with early onset Alzheimer's disease led us to explore its neural expression. Our data support and extend the previous reports on ABCA2 expression by oligodendrocytes. They evidence that ABCA2 (i) is located in intracellular vesicles, identified in transfected cells as lysosome‐related organelles only partially overlapping with classical endolysosomes; (ii) is a marker of neural progenitors as it is expressed in the subventricular zone of the lateral ventricle and the dentate gyrus of the hippocampal formation, sites of continual neurogenesis in the adult brain, and in nestin + cells differentiated in vitro from embryonic stem cells; (iii) persists, in the adult rodent brain, in a subset of GABAergic and glutamatergic neurons. Considering that the latter are targets of Alzheimer's lesions, these data provide a new rationale to explore the neuropathological consequences of ABCA2 functional dysregulations.