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Axonal regeneration in adult CNS neurons – signaling molecules and pathways
Author(s) -
Teng Felicia Yu Hsuan,
Tang Bor Luen
Publication year - 2006
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.2006.03663.x
Subject(s) - neuroscience , creb , biology , cyclic amp response element binding protein , signal transduction , transcription factor , regeneration (biology) , leukemia inhibitory factor , dorsal root ganglion , microbiology and biotechnology , crosstalk , neurotrophic factors , inhibitory postsynaptic potential , stat protein , central nervous system , axon , stat3 , spinal cord , cytokine , immunology , receptor , interleukin 6 , optics , biochemistry , physics , gene
Failure of severed adult CNS axons to regenerate could be attributed to both a reduced intrinsic capacity to grow and an heightened susceptibility to inhibitory factors of the CNS extracellular environment. A particularly interesting and useful paradigm for investigating CNS axonal regeneration is its enhancement at the CNS branch of dorsal root ganglion (DRG) neurons after conditional lesioning of their peripheral branch. Recent reports have implicated the involvement of two well‐known signaling pathways utilizing separate transcription factors; the Cyclic AMP (cAMP) response element binding protein (CREB) and signal transducer and activator of transcription 3 (STAT3), in conditional lesioning. The former appears to be the pathway activated by neurotrophic factors and Bcl‐2, while the latter is responsible for the neurogenic effect of cytokines [such as the leukemia inhibitory factor (LIF) and interleukin‐6 (IL‐6) elevated at lesion sites]. Recent findings also augmented earlier notions that modulations of the activity of another class of cellular signaling intermediate, the conventional protein kinase C (PKC), could result in a contrasting growth response by CNS neurons to myelin‐associated inhibitors. We discuss these signaling pathways and mechanisms, in conjunction with other recent reports of regeneration enhancement and also within the context of what is known about aiding regeneration of injured CNS axons.