Premium
Increased dopamine release in vivo by estradiol benzoate from the central amygdaloid nucleus of Parkinson's disease model rats
Author(s) -
Liu Bin,
Xie Junxia
Publication year - 2004
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.2004.02518.x
Subject(s) - dopaminergic , amygdala , dopamine , estradiol benzoate , parkinson's disease , medicine , endocrinology , ovariectomized rat , neuroscience , oxidopamine , basal ganglia , neuroprotection , chemistry , estrogen , nucleus accumbens , mesolimbic pathway , central nervous system , psychology , ventral tegmental area , substantia nigra , disease
Abstract In addition to the dopaminergic neurons in the nigrostriatal system, the properties of dopaminergic neurons in the mesolimbic system, such as the amygdala, are also of interest and importance because of their specific neuromodulatory effects in the pathophysiology of Parkinson's disease (PD). Using the fast cyclic voltammetry (FCV) technique, we present evidence to indicate that electrically‐evoked dopamine (DA) release from the amygdala, especially the central amygdaloid nucleus (CAN), of ovariectomized (OVX) female rats was significantly enhanced with increasing doses of estradiol benzoate (EB; 30, 50 and 100 µg/kg). Impaired DA release from the amygdala of an OVX rat PD model can also be increased by EB treatment (50 µg/kg) to a level similar to that of controls. The well established neuroprotective effects of estrogen may be beneficial for reducing the dysfunction of dopaminergic neurons in mesolimbic structures of rat PD models and PD patients.