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Free Fatty Acid and Diacylglycerol Accumulation in the Rat Brain During Recurrent Seizures Is Related to Cortical Oxygenation
Author(s) -
Visioli F.,
Rihn L. L.,
Rodriguez de Turco E. B.,
Kreisman N. R.,
Bazan N. G.
Publication year - 1993
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1993.tb09824.x
Subject(s) - ictal , medicine , endocrinology , cerebral cortex , oxygenation , cerebral blood flow , basal (medicine) , epilepsy , cortex (anatomy) , chemistry , biology , neuroscience , insulin
— Cerebral blood flow and oxygenation increase during the early seizures of a series, but the increase in cerebral blood flow attenuates during late seizures, sometimes resulting in decreased cortical oxygenation. Cortical free fatty acids (FFA) and diacylglycerols also increase during early seizures and the increase attenuates during late seizures. We analyzed the correlation between lipid accumulation and cortical O 2 during periodic pentylenetet‐razol‐induced seizures. During early seizures, both FFA and diacylglycerols increased in the cerebral cortex, particularly arachidonate (20:4) and stearate (18:0). Changes in lipids were different during late seizures, depending on cortical O 2 levels. An increase in cortical O 2 during late seizures was associated with lower FFA levels compared with early seizures, and FFA levels recovered to basal levels during interictal periods. A decline in cortical O 2 was associated with a further increase in FFA, which remained elevated during interictal periods. Our results indicate that periseizure lipid accumulation is related to cortical oxygenation.