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The Protooncogene bcl‐2 Inhibits Apoptosis in PC12 Cells
Author(s) -
Mah S. P.,
Zhong L. T.,
Liu Y.,
Roghani A.,
Edwards R. H.,
Bredesen D. E.
Publication year - 1993
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1993.tb03275.x
Subject(s) - apoptosis , programmed cell death , microbiology and biotechnology , biology , immune system , stimulation , calcium , cell culture , immunology , endocrinology , cancer research , medicine , genetics
During development, many neuronal populations undergo a process of normal, programmed cell death, or apoptosis. Trophic factors regulate this process, but the mechanism by which they suppress apoptosis remains unclear. In the immune system, recent studies have implicated the protooncogene bcl‐2 in the lymphocyte survival response to growth factors. To determine whether a similar survival pathway exists in a neuroendocrine cell type, we have expressed bcl‐2 in the rat pheochromocytoma PC12 cell line and found that it abrogates the requirement for stimulation by growth factors to survive. bcl‐2 expression also substantially delays the onset of injury by the calcium ionophore A23187.