Premium
Protection Against Acute MPTP‐Induced Dopamine Depletion in Mice by Adenosine A 1 Agonist
Author(s) -
Lau YuenSum,
Mouradian M. Maral
Publication year - 1993
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1993.tb03215.x
Subject(s) - mptp , agonist , adenosine , dopamine , dopamine agonist , pharmacology , chemistry , neuroscience , endocrinology , medicine , biology , receptor , dopaminergic
The effects of the adenosine A 1 agonist N 6 ‐cyclohexyladenosine (CHA) on MPTP‐induced dopamine (DA) depletion in the striatum of C57BL/6 mice were studied. Twenty hours after a single injection of MPTP (30 mg/kg, s.c.), the toxin caused 62% depletion of striatal DA. CHA (0.2–3 mg/kg, s.c.), when given together with MPTP, prevented the toxin‐induced DA depletion in a dose‐dependent manner. This protective action was apparently mediated by the A 1 receptors, because this effect was selectively antagonized by pretreating the animals with the A 1 antagonist 8‐cyclopentyl‐1,3‐dipropylxanthine (25 mg/kg, i.p.) but not with the A 2 antagonist 1,3‐dipropyl‐7‐methylxanthine (25 mg/kg, i.p.). When CHA (3 mg/kg) was injected 5 h after MPTP administration, at which point striatal DA levels were already reduced significantly, a rapid and complete recovery of the striatal DA levels occurred. These neurochemical data suggest that the A 1 agonist CHA is potentially useful as a neuroprotective agent against MPTP‐induced toxicity.