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Dopamine D 2 Receptor‐Mediated Regulation of Serotonin Extracellular Concentration in the Dorsal Raphe Nucleus of Freely Moving Rats
Author(s) -
Ferré Sergi,
Artigas Francesc
Publication year - 1993
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1993.tb02187.x
Subject(s) - dorsal raphe nucleus , raclopride , raphe nuclei , chemistry , agonist , ventral tegmental area , dopamine , serotonin , medicine , serotonergic , autoreceptor , microdialysis , endocrinology , apomorphine , 5 ht receptor , sch 23390 , dopaminergic , biology , receptor , biochemistry
Morphological and pharmacological data suggest the existence of a reciprocal interaction between the mesencephalic dopamine (DA) system and the serotonin (5‐HT) system originating in the dorsal raphe nucleus (DRN). In the present work, a DA D 2 receptor‐mediated regulation of 5‐HT extracellular concentrations in the DRN is described, by using brain microdialysis in freely moving rats. Local infusion of the nonselective DA agonist apomorphine produced a dose‐dependent increase in the extracellular concentration of 5‐HT in the DRN, which was prevented by previous infusion of the specific D 2 antagonist raclopride but not of the D, antagonist SCH‐23390. Furthermore, local infusion of the selective D 2 agonist LY‐171, 555 increased extracellular 5‐HT levels in the DRN, and this effect was also prevented by the previous infusion of raclopride. It is postulated that DA, either from projections from the substantia nigra or the ventral tegmental area or from the DA‐containing neurons of the DRN, may increase 5‐HT release in the DRN, which, through autoreceptor stimulation, can profoundly influence the activity of ascending serotoninergic neurons.