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Fucosyl‐GM1 in Human Sensory Nervous Tissue Is a Target Antigen in Patients with Autoimmune Neuropathies
Author(s) -
Yoshino Hiide,
Ariga Toshio,
Latov Norman,
Miyatake Tadashi,
Kushi Yasunori,
Kasama Takeshi,
Handa Shizuo,
Yu Robert K.
Publication year - 1993
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1993.tb02170.x
Subject(s) - sensory system , neuroscience , nervous system , nervous tissue , antigen , biology , immunology , medicine
Several gangliosides of human nervous tissues have been reported to be potential target antigens in autoimmune neuropathies. To explain the diversity of clinical symptoms in patients with antiganglioside antibodies, we have searched for ganglioside antigens that are specific to individual nervous tissues such as motoneurons, peripheral motor nerves, and sensory nerves. Although the major ganglioside compositions were not different among human peripheral motor and sensory nerves, fucosyl‐GM1 was found to be expressed in sensory nervous tissue but not in spinal cord, motor nerve, and sympathetic ganglia. Sera from several patients with sensory nerve involvement also reacted with fucosyl‐GM1 as well as GM1. Thus, fucosyl‐GM1 may be a responsible target antigen for developing sensory symptoms in some patients with autoimmune neuropathies.