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Adrenalectomy Potentiates Immediate Early Gene Expression in Rat Brain
Author(s) -
Li Xiaohua,
Song Ling,
Kolasa Krystyna,
Jope Richard S.
Publication year - 1992
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1992.tb10982.x
Subject(s) - kainate receptor , junb , adrenalectomy , medicine , endocrinology , corticosterone , glucocorticoid , hippocampal formation , immediate early gene , hippocampus , c fos , stimulation , messenger rna , chemistry , gene expression , biology , hormone , nmda receptor , gene , receptor , biochemistry , ampa receptor
Abstract: Administration of kainate or pentylenetetrazole increased c‐ fos , c‐ jun, junB , and junD mRNA levels in rat brain in a dose‐dependent manner. Kainate increased these mRNA levels predominantly in the hippocampus, and pentylenetetrazole was more effective in the cortex. Adrenalectomy (3 days) was used to eliminate endogenous glucocorticoid hormones. Adrenalectomy significantly potentiated kainate‐induced increases, compared with increases caused by kainate (4 mg/kg) alone, in the hippocampal mRNA levels of c‐ fos and junB by 6.5‐fold and of junD by twofold and tended to augment c‐ jun mRNA. Corticosterone administration blocked the potentiated stimulation of these mRNA levels caused by adrenalectomy. Adrenalectomy also significantly increased pentylenetetrazole‐induced levels of c‐ fos mRNA in the cortex. These results demonstrate that glucocorticoids modulate immediate early gene expression in the brain, raising the possibility that this interaction contributes to interneuronal and interindividual differences in responses to stimuli and to the effects of stress‐ or disease‐induced changes in glucocorticoid concentrations.