Premium
Specific Irreversible Monoamine Oxidase B Inhibitors Stimulate Gene Expression of Aromatic L‐Amino Acid Decarboxylase in PC12 Cells
Author(s) -
Li XinMin,
Juorio Augusto V.,
Paterson I. Alick,
Zhu MengYang,
Boulton Alan A.
Publication year - 1992
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1992.tb10127.x
Subject(s) - clorgyline , pargyline , monoamine oxidase b , aromatic l amino acid decarboxylase , monoamine oxidase , chemistry , monoamine oxidase a , biochemistry , enzyme , gene expression , monoamine oxidase inhibitor , gene
The effect of some selective monoamine oxidase (MAO) inhibitors on aromatic L‐amino acid decarboxylase (AADC) gene expression in PC12 cells has been examined. Irreversible MAO B inhibitors [(–)‐deprenyl, pargyline, and MDL 72,974A] stimulated AADC gene expression, whereas a selective irreversible MAO A inhibitor (clorgyline) and a reversible MAO B inhibitor (Ro 19‐6327) had no effect. Because there is no apparent MAO B activity in PC12 cells, it is postulated that there is a novel site of action for these MAO B inhibitors and that the pharmacological profile of this site matches that of neuroprotective MAO B inhibitors. Finally, it is suggested that the stimulation of AADC gene expression may be relevant to the antiparkinsonian effects of MAO B inhibitors.