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Determination of Acidic Metabolites of Biogenic Amines in Human Aqueous Humour by Gas Chromatography‐Negative Ion Chemical Ionisation Mass Spectrometry
Author(s) -
Watson David G.,
McGhee Charles N. J.,
Midgley John M.,
Zhou Ping,
Doig William M.
Publication year - 1992
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1992.tb09285.x
Subject(s) - homovanillic acid , chemistry , metabolite , chromatography , octopamine (neurotransmitter) , aqueous solution , aqueous humour , dopamine , mass spectrometry , tyramine , 3,4 dihydroxyphenylacetic acid , aqueous humor , biochemistry , organic chemistry , endocrinology , serotonin , medicine , receptor , ophthalmology
Abstract: The concentrations of acidic metabolites derived from the biogenic amines o‐, m‐ , and p ‐tyramines ( o‐, m‐ , and p ‐hydroxyphenylacetic acids), p ‐octopamine/ p ‐synephrine ( p ‐hydroxymandelic acid), and dopamine (homovanillic acid and 3,4‐dihydroxyphenylacetic acid) were measured in human aqueous humour obtained from patients undergoing elective surgery for cataract removal or for trabeculectomy as a treatment for chronic open‐angle glaucoma. There were no clear differences in the pattern of metabolism of neurotransmitters between the two groups. An unexpected finding was that the o ‐tyramine metabolite, o ‐hydroxyphenylacetic acid, was present in aqueous humour.