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Endogenous Dopamine Facilitates Striatalln Vivo Acetylcholine Release by Acting on D 1 Receptors Localized in the Striatum
Author(s) -
Consolo Silvana,
Girotti Prisca,
Russi Giovanni,
Chiara Gaetano Di
Publication year - 1992
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1992.tb08473.x
Subject(s) - sch 23390 , striatum , acetylcholine , dopamine , chemistry , antagonist , medicine , pharmacology , amphetamine , neurotransmitter , endocrinology , dopamine antagonist , dopamine receptor , receptor , biology , biochemistry
Intrastriatal application of the D 1 antagonist SCH 23390 by two procedures, reverse dialysis (20 μ M ) and local injection (0.45 nmol per striatum), elicited a reduction in acetylcholine (ACh) release superimposable on that induced by systemic administration. The novel selective D 1 antagonist SCH 39166 produced a similar decreasing effect on striatal ACh release on local injection (0.45 nmol per striatum). On the other hand, local application of SCH 23390 into the frontal cortices (0.45 nmol per side) failed to alter striatal ACh overflow, indicating that the drug does not diffuse out of its injection site to any significant extent. The dopamine release inducer d ‐amphetamine (2 mg/kg s.c.) and the dopamine uptake inhibitor cocaine raised ACh release like the D 1 agonists. These effects were completely blocked by 10 μ M SCH 23390 applied by reverse dialysis. The results suggest that D 1 receptors regulating ACh release are located in the striatum.