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Differences in the Pharmacokinetics of Cocaine in Naive and Cocaine‐Experienced Rats
Author(s) -
Pan HwaiTzong,
Menacherry Stanley,
Justice J. B.
Publication year - 1991
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1991.tb11425.x
Subject(s) - pharmacokinetics , intraperitoneal injection , medicine , pharmacology , absorption (acoustics) , anesthesia , drug , route of administration , adipose tissue , physics , acoustics
Enhanced cocaine concentrations in brain and blood observed after an intraperitoneal challenge dose in rats exposed to cocaine for 10 days by subcutaneous administration are traced to a change in the absorption process from the site of an intraperitoneal injection to general circulation. This conclusion is reached by three sets of corroborating results: (a) Adipose tissue of rats treated for 10 days with repeat subcutaneous injections of cocaine did not reveal a buildup of cocaine in sufficient concentrations to account for the twofold increase in brain and blood concentrations seen during intraperitoneal administration; (b) administration of the drug by an intravenous route after 10‐day cocaine treatment did not show a significant difference between treatment and control groups; (c) nonlinear regression on the intravenous and intraperitoneal data sets using a two‐compartment open model indicated a difference in the absorption process but not in the metabolic and blood‐brain transfer processes.