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Evidence for Atrial Natriuretic Peptide (ANP) Synthesis and the Presence of ANP‐Transducing Receptors in the Rat Olfactory Bulb
Author(s) -
Gutkowska J.,
Tremblay J.,
Meyer R.,
Marcinkiewicz M.,
Nemer M.
Publication year - 1991
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1991.tb06395.x
Subject(s) - atrial natriuretic peptide , olfactory bulb , receptor , medicine , olfaction , npr1 , endocrinology , chemistry , npr2 , olfactory system , biology , peptide , neuroscience , natriuretic peptide , biochemistry , central nervous system , heart failure
This study demonstrates the presence of both atrial natriuretic peptide (ANP) precursor and ANP transcripts in the rat olfactory bulb (OB), a key brain structure involved in the generation of olfaction‐dependent behavior. In addition to synthesizing ANP, the OB contains ANP‐transducing receptors coupled to the guanylate cyclase system but it is devoid of ANP “clearance receptors.” The characterization of biologically active ANP receptors and the evidence for in situ ANP synthesis in this region of the CNS adds credence to the hypothesis that the peptide plays a putative role in olfaction.